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This paper is a comprehensive prospective casecontrol study that first reported the high prevalence of the metabolic syndrome in patients with HS, an observation most striking among young patients

FGF21 also appears to mediate some of the effects of hepatic glucagon and thyroid hormone signaling, since both activation of glucagon receptor (GCGR) (106) and thyroid hormone receptor- (TR-) (107) induce secretion of FGF21 by hepatocytes