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Additionally, TLR4 signaling triggers the extracellular signal-regulated kinase and p38 MAPK pathways, further increasing the expression of downstream molecules and promoting the production of TNF- and other inflammatory cytokines and chemokines [51, 52]

This can be done through an IV drip, a small needle inserted into a vein in the arm or hand

Pallone TL, Freedman DA (2021) The role of the blood-brain barrier in neurodegeneration

Casticin could inhibit platelet aggregation, release, adhesion and plaque retraction, which was achieved by inhibiting PI3K/Akt signaling pathway (Xiong et al., 2022)