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Tang, F., Ling, C

The following occurred in the respective cases: sodium and chloride depletion fluid overload septicemia, or blood poisoning, in an individual with existing compromised liver function and portal hypertension While underlying conditions may have increased the risk of severe side effects or death in some cases, these findings suggest that coffee enemas are generally not safe

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Some research models note mild observations including gastrointestinal effects in certain experimental protocols