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Biochemical changes in intervertebral disc degeneration

Serum B12 below 100 pmol/L post-RYGB: This is the scenario in which I am most conservative

Additionally, SDF-1 inhibits GSK3 activation by binding to the specific receptor CXCR4 and activating the PI3K-Akt pathway, thereby enhancing -catenin gene expression and facilitating the recruitment of MSCs and endothelial progenitor cells to injury sites [70]