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Therefore, we administered a lower dose (60 mg/kg) of NaOX to Fsp1 wt/wt Ksp Cre-ERT2 and Fsp1 fl/fl Ksp Cre-ERT2 mice

JHU-083 markedly suppresses the recruitment of MDSCs by decreasing tumor-derived CSF3 levels via degradation of C/EBP, which in turn increases the numbers of proinflammatory TAMs and enhances antigen presentation to CD8(+) T cells, resulting in stronger T-cell responses 150