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In many neurological diseases, comprising both neurodegenerative and neurodevelopmental disorders, alterations in DNA methylation occur at specific genomic regions, including gene promoters, enhancers and CpG islands (25)

A recent genomic study identified PPP6R3::FHDC1 and MYH9::MYH6 fusions in two of three cases ( GSTT1::IGLC7 fusion, suggesting that the molecular genetic heterogeneity of MELTVR may be greater than previously recognized

9 Impact of environmental factors on AA development Environmental factors, as in many other diseases, are considered significant contributors to both the onset and exacerbation of AA

Loss of pregnancy-associated plasma protein A extends lifespan in mice