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In a previous double-blind placebo-controlled phase II trial, 42 self-sufficient subjects (with a score of 3+ on the ALSFRS-R items for swallowing, cutting food and handling utensils, and walking) with ALS [10] received ALCAR 3 g/day and 40 received placebo in an equivalent dose, and were followed for 12 months or until death [11]

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