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Symptoms associated with low IGF-1 may include: Reduced muscle mass Fatigue Poor exercise recovery Increased abdominal fat Reduced bone density Slower healing Difficulties with cognitive functioning Poor spatial working memory Low energy Frailty Adults with growth hormone deficiency often experience decreased quality of life, reduced physical performance, and metabolic dysfunction

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doi: 10.3390/ijms241814113 Summary Keywords Piezo1, CNS diseases, biological properties, Ca2+, pharmacology Citation Xu Y, Wang Y, Yang Y, Fang X, Wu L, Hu J, Li J and Mei S (2024) Piezo1: the key regulators in central nervous system diseases