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Abbreviations AIF apoptosis-inducing factor ALF acute liver failure ALT alanine aminotransferase APACHE II acute physiology and chronic health evaluation II APAP acetaminophen AST aspartate transaminase ATP adenosine triphosphate DAMP damage-associated molecular pattern DILI drug-induced liver injury EndoG endonuclease G FDA Food and Drug Administration GDCA glycodeoxycolic acid GDH glutamate dehydrogenase GSH glutathione HMGB1 high mobility group B1 HPLC high-pressure liquid chromatography INR international normalized ratio IV intravenous JNK c-Jun-N-terminal kinase KCH Kings College Hospital KIM 1 kidney injury molecule 1 MELD model for end-stage liver disease miRNA microRNA mtDNA mitochondrial DNA NAC N -acetyl cysteine NAPQI N -acetyl-para-benzo-quinone imine nDNA nuclear DNA NK natural killer NKT natural killer T cells PO oral SFN sulforaphane SOFA sequential organ failure assessment SULT sulfotransferase UGT UDP-glucoronosyl transferase References 1.Bunchorntavakul C, Reddy KR