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Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

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Price 1 , Andrei Racila 1 and Maria Stepanova 5 , (1)Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, (2)Center for Liver Disease, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, (3)Inova Medicine, Inova Health System, Falls Church, VA, (4)Division of Endocrinology, Inova Health System, Falls Church, VA, (5)Center for Outcomes Research in Liver Diseases, Washington, DC Background: Genetic risk factors have been linked to histologic stage of fibrosis in NAFLD