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The clinical efficacy of PRP is intrinsically linked to the concentration of platelets and the subsequent release of a plethora of growth factors, notably VEGF, platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-1 and TGF-2), epithelial growth factor (EGF), and insulin-like growth factor (IGF) [27,28]

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Antioxidants are substances that inhibit the oxidation of other molecules

Genes whose suppression allowed cells to resist Cu but not vinblastine (Supplementary Dataset 1) were considered as Cu-specific hits and studied further, while genes corresponding to shRNAs conferring resistance to both vinblastine and copper were discarded (see vinblastine screening results in Supplementary Dataset 2)