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Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)-based editing have enabled targeted correction of nonsense mutations [184, 185]

78 Thus, the impact of astrocytic lactylation is defined by its specific downstream molecular targets rather than a generalized inflammatory response (Table 2)

An SMN-dependent U12 splicing event essential for motor circuit function

This mitochondrial failure results in the immune senescence of those same T cells and a systemic accelerated aging phenotype, marked by motor deficits, cardiovascular dysfunction, and cognitive decline (Desdn-Mic et al., 2020)