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Together, these findings suggest that ferroptosis contributes to HD pathology, and its inhibition may represent a viable strategy for disease modification ( Figure 9 )

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Only during the past few years have other targeted therapies (JAK1/2, ROCK2, BTK, anti-CSF-1R antibody) gained approval as second-line treatment for chronic GVHD, with real-world data concerning their efficacy still under evaluation

[64] Celiac disease is closely linked to gluten allergy, but negative findings from controlled studies seemed to rule out any central role for gluten allergies in MS