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The Kendalls tau analysis found positive correlations that were significantly different from 0 in the HC group, for cross-pathway purine and monoamine metabolite pairs ( Table 2 ) as follows: (1) for UA with TRP, 5-HIAA, MEL, KYN, and TYR

The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation

This interaction decreases the channels sensitivity to iron ions, restricts the efflux of molecules from mitochondria, and induces mitochondrial dysfunction

In therapeutic settings, the effects of global GSH depletion or supplementation are likely to depend on disease context and cellular state