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Injecting randomly throughout the day produces isolated pulses that may not align with downstream anabolic pathways, reducing the metabolic impact per injection

doi: 10.1371/journal.ppat.1011371 82 FongGHTakedaK

The superoxide radical is formed during the infection by activated phagocytes to kill the microorganisms

Moreover, elevated AR activity may impair antioxidant defences through NADPH depletion, thereby limiting glutathione (GSH) regeneration and exacerbating oxidative stress 10,52 ( Figure 7 )