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Pathogenesis is believed to start with occlusion and dilation of the pilosebaceous unit rupture extrusion of follicular contents into dermis chemotactic inflammatory response influx of neutrophils, lymphocytes, histiocytes abscess formation (thus, it is both an inflammatory disease related to immune dysregulation and infectious disease)

Over two hours, the participants received either four 2-minute active stimulation sessions (n = 10) or four 2-minute sham stimulation sessions (n = 11)

Moreover, the PGC-1/ERR axis directly promotes the expression of key fusion and fission genes

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