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10.1016/j.jep.2019.112404 130 WuQ.ChangX.WangY.LiuJ.GuanX.LiuZ.et al (2024)

Passive Immunotherapy Two placebo-controlled phase 2 trials of monoclonal anti--synuclein antibodies ( prasinezumab and cinpanemab ) have also failed to meet their primary endpoints of change from baseline to week 52 or 76 in combined MDS-UPDRS part I + II + III scores [207, 208]

BPC-157 does not directly improve sleep through hormonal mechanisms, though reducing chronic pain or inflammation may indirectly improve sleep quality in patients whose sleep is disrupted by physical discomfort

Park et al., 2014 reported that cardamomin has an anti-nociceptive effect as it dose-dependently inhibited Tgase-2, p65, and COX-2 and restored IB expression in MG63 osteoblast-like and RAW 264.7 cells