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The mTOR signaling can be activated by three board categories of instructive signals, encompassing environmental cues (e.g., growth factors and immunoregulatory factors), immune signals (e.g., co-stimulation, antigens, and cytokines), and nutrients (e.g., essential amino acids and glucose) (98)

Because cell viability and apoptosis were not directly assessed in this study, it is difficult to conclude if caspase-3 activation was accompanied by increased apoptosis (Bonnard et al., 2008)

*Correspondence: Daniele Di Marino [email protected] This article was submitted to Child and Adolescent Psychiatry, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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