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Clinical patterns of facial melasma Reproduced with permission from Gupta M, Doolan BJ, Manungo F, Diagnosis of melasma and diagnostic tools, Opinions & Progress in Cosmetic Dermatology 2020;1:1518

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Moreover, animal studies have reported that pre-treatment with metformin could reduce both myocardial and cerebral I/R injury (203, 204)

Overview of ferroptosis Mechanism of ferroptosis Dysfunction iron metabolism and oxidation of lipids Many biochemical and metabolic activities rely on Fe 2+ , including energy metabolism, oxygen transport, and the cellular mitochondrial synthesis of iron-sulfur proteins