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(II) C-Met is modulated through crosstalk with different membrane receptors, including epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER), Integrin, - catenin, cluster of differentiation-44 (CD44), intercellular adhesion molecule-1 (ICAM-1), Plexin B1, VEGF-A, insulin receptor (INSR), FAS, Mucin 1 (MUC1), neuropilin (Nrp)-1 and -2, and focal adhesion kinase (FAK) (Figure 2