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The key secondary efficacy endpoint was time to first event of clinical worsening, defined as a composite endpoint of all-cause mortality, hospitalization for worsening PAH or disease progression

The specific molecular mass allows for precise quantification using mass spectrometry and other analytical techniques

A minimum of 98% is considered research grade, though 99% is strongly preferred for sensitive assays, cell culture experiments, and in vivo pre-clinical studies where compound purity directly affects reproducibility and result accuracy

For a medicine to earn clear dosing guidance, researchers generally need repeated studies, defined outcomes, safety data, and a regulated product