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Caspase activation was also performed and the data totally confirmed these observations, with higher sensitivity for A549 shNRF2 and increased resistant for H23 NRF2 cell lines (Supplementary Fig

GHK-Cus documented NGF stimulation appears to sit within its broader gene expression modulation signature rather than representing a direct receptor interaction, which is mechanistically coherent with the transcriptomic reactivation data showing GHK-Cu shifting aging gene expression profiles toward younger patterns (PMID: 25904764)

While in Firoc mice ip IGF-I did not affect LC responses in the PeF area (n=10), in control animals ip IGF-I significantly increased the response area (n=10