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TrkB neurotrophic activities are blocked by alpha-synuclein, triggering dopaminergic cell death in Parkinson's disease

Furthermore, the primary sources of free radicals during cerebral ischaemia-reperfusion include calcium-dependent oxidative enzymes such as xanthine oxidase, NADPH oxidase, and nitric oxide synthase, as well as the degradation of membrane and mitochondrial phospholipids [14]

Contemporary research indicates that neoplastic cells undergoing ferroptosis may also discharge DAMPs into the extracellular milieu through autophagy, thereby enlisting and stimulating immune cells

Long-term disc health requires ongoing attention to the factors that caused or contributed to the herniation in the first place