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NASH can lead to fibrosis, and scarring of the liver, and may progress to cirrhosis or liver cancer if left untreated

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FIGURE 3 Furthermore, a thorough mutagenesis study of Md ACO1, identified other important residues essential for ACO activity: C28, T157, K158, R175, Q188, K199, K230, R244, S246, K292, E294, E297, R299, F300, and E301 (Zhang et al., 2004