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Their use is limited, though, by teratogenic and hepatotoxic side-effects [5658]

Ipamorelin is studied as a selective ghrelin mimetic it binds the growth-hormone-secretagogue receptor (GHSR-1a), the same receptor the hunger hormone ghrelin uses, and in research settings appears to stimulate GH release with relatively limited effect on other hormones such as cortisol, prolactin, and ACTH

These findings support the concept that LPO is not only a marker but also a driver of AD pathology and that targeting LPO may offer therapeutic benefits by suppressing ferroptosis