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For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

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The interplay of these hormones is complex, regulating a wide range of physiological processes and contributing to the bodys ability to adapt to both short-term and long-term stressors ( 3 General overview of adrenal hormone disorders Adrenal hormone disorders, also called adrenal gland disorders, are characterized by dysfunction or imbalance in the hormones produced by the adrenal glands

doi: 10.1073/pnas.2219569120