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These changes can be influenced by environmental factors and may contribute to the dysregulation of immune responses observed in GD ( CD247 , CD3D , CD3E , CD3G , CD8A , LCK , ZAP70 , and CTLA4 , show decreased H3K4me3 levels in their promoters, leading to downregulation of their expression in both CD4+ and CD8+ T cells of GD cases ( Stress and psychological factors Stress and psychological factors have been implicated in the development of autoimmune diseases, including GD

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