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MetS is related with an increased risk of CVD, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM) and subsequent mortality (Ford, 2005[15]

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Thus, unlike the DR-1 element positioned close to the SHBG transcription start site, and which functions through interactions with COUP-TF and HNF-4 as the main transcriptional on-off switch in the liver 8 , the upstream DR-1 element that interacts with CAR may represent a fine-tuner that responds to a number of related NHRs many of which regulate responses to metabolic disturbances during disease or after exposure to drugs or environmental xenobiotic ligands

L-carnitine reduces body weight L-carnitine balances blood sugar L-carnitine improves insulin resistance L-carnitine regulates the menstrual cycle L-carnitiine lowers testosterone levels This is why it can be so helpful, if it can help with insulin & testosterone balance, help with weight loss & your cycle, it can actually play a really important role in improving your PCOS overall