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However, any combination should be approached thoughtfully with consideration of individual factors

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Change history 16 April 2021 A Correction to this paper has been published: Abbreviations SC: Subcutaneous IM: Intramuscular IV: Intravenous AUC 0-t : Area under the curve from t0 to t480 min (last time point sampled) AUC 0- : Area under the curve from t0 to infinity t max : Time of maximum concentration C max : Maximum concentration C 0 : Concentration at time point 0 t : Elimination half life F: Bioavailability NZW: New Zealand White References Commission E

Phase II at minimum, with a credible safety analysis