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Randleman: Christopher Cardenas-Mercado (Degree), Michael Ray Davis Jr

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32 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Example of deconjugation of acyl glucuronides in systemic circulation in humans Valproic acid glucuronide an acyl glucuronide(data in monkeys) Doripenem (S4661) Inhibition of valproic acid glucuronide cleavage in vivo carbapenem antibiotics, thus increasing the clearance of VPA, and decreasing the exposure to VPA is observed in humans resulting in failure of antisiezure medication. Putative inhibition of systemic cleavage of VPAglucuronide by carbapenem blocking hydrolytic enzymes, (possibly carbamoylation of the serine active site of the enzymes?)Kojima S, et al

Jena GB, Kaul CL, Ramarao P