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Increased protein expression as a consequence of transcriptional upregulation in the absence of gene amplification is the most frequent cause of constitutive c-MET activation in human tumors [Comoglio et al

Some animal studies have reported re-pigmentation in gray hair follicles following exposure to this compound, mediated through effects on melanocyte activity in the follicle

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The dose-response relationship with sleep disruption appears roughly linear: higher doses correlate with more pronounced effects