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Results are presented as the mean standard deviation (SD) of three separate experiments

GSH is involved in numerous vital functions such as detoxifying electrophiles, scavenging free radicals, maintaining the thiol status of proteins, providing cysteine, modulating DNA synthesis, microtubular-related processes, nitric oxide homeostasis, the activity of neuromodulators as well as immune functions (reviewed in Lu 2009)

Beyond disulfide bonds, diselenide bonds (-SeSe-) have also been employed in GSH-responsive DDSs, owing to seleniums chemical similarity to sulfur, as both elements belong to Group VI of the periodic Table [58]

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Gray L.R., Tompkins S.C., Taylor E.B