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Additional biosynthetic pathways have been elucidated, demonstrating glucose conversion through multiple intermediates, including pyruvate, phosphoenolpyruvate, erythrose-4-phosphate, shikimate-3-phosphate, and chorismate, proceeding through enzymatic steps catalyzed by prephenate dehydrogenase, prephenate dehydratase, and related enzymes to yield the final coumarin product (Yang et al

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1,8 Cysteine occurs in plasma in the following forms: the solitary amino acid with its free thiol group (free cysteine), a disulfide between 2 molecules of cysteine (cystine), and a mixed disulfide with cysteinyl residues of albumin or other plasma proteins (protein-bound cysteine)

This is probably due to the differing levels of susceptibility of different brain regions to OS