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In some embodiments, preparation of certain cations of the invention may occur via oxidation of quinoline (using e.g., mCPBA) followed by nitration and chlorination, respectively and further followed by amination and alkylation, respectively, as exemplified with the preparation of cation 2k (Scheme 4)

[DOI] [PubMed] [Google Scholar] 41.Wagner, S., Manickam, R., Brotto, M

Key Research Properties: Small molecule NNMT (nicotinamide N-methyltransferase) inhibitor Modulates NAD+ metabolism and methylation capacity Studied in context of energy expenditure and metabolic regulation NNMT is upregulated in obesity

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