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Subsequently, reduced iron Fe 2+ enters enterocytes through divalent metal transporter-1 (DMT1) in the apical membrane (51), is transported into the blood circulation through Ferroportin1 (FPN1) on the intestinal epithelial cell membrane, and is then converted to Fe 3+ by heparin (Hp) or ceruloplasmin (52)

Promotes the release of stored toxins

These proteases include thrombin [141,142,143,144], factor Xa [141,145], enterokinase [146], human rhinovirus (HRV) 3C protease/PreScission Protease [147], and tobacco etch virus (TEV) protease [148]

Investigators have assessed multiple administration routes, including subcutaneous, intramuscular, intravenous, oral, and topical delivery in experimental models