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2 Estrogen receptors are found on cells throughout the body, and fluctuating or low estrogen levels are thought to cause the symptoms that characterize peri- and postmenopause by affecting temperature regulation, mood, skin, bones, and urogenital tissues, as well as cardiovascular, cognitive, and metabolic function

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This reconstitution guide is for educational purposes only

Those in the methotrexate and folic acid group had received a mean (SD) cumulative methotrexate dose of 184 (72) decigrams over 11 (4) years and had a mean (SD) age of 63 (11) years compared to 59 (11) years for patients on other therapies (Table 1)