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It dramatically amplifies and accelerates the underlying disease process

Interestingly, we used a Tg(Xla.Tubb:bcl-2) transgenic line, in which zebrafish bcl-2 mRNA is overexpressed specifically in neurons under the control of a Xenopus neuron-specific -tubulin ( Xla.Tubb ) promoter, and Bcl-2 overexpression considerably reduced the number of apoptotic neuronal cells, which had been increased by sulindac (Fig

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In the case of oculodermal melanosis or primary acquired melanosis, the risk of melanoma is much increased