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We are also finalizing at 428.202(d)(3), with modifications to 428.202(c)(3) and (4), the first alternative policy described in the CY 2025 PFS proposed rule (89 FR 61966) to calculate the benchmark period manufacturer price for a new NDC-9 of a Part D rebatable drug using information reported by a manufacturer under section 1927(b)(3) of the Act for the Part D rebatable drug, as available, including base date AMP if such base date AMP is reported for a calendar quarter that overlaps with the period described at 428.202(c)(1) or (2)

Clinicians may choose to administer this formulation of hydromorphone if the patient requires constant administration of opioids or needs higher dosages of opioids than would otherwise be possible with alternative forms of pain management (59)

Thus, 18F-(2S,4R)4-fluoroglutamine PET could be a novel method for identifying glutamine metabolism in cancer patients and directing the use of glutamine therapy that is specifically targeted [52]