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Rather than positioning OSCs as stand-alone antimicrobials, we frame them as adjunctive agents with plausible utility in settings where conventional antibiotics show persistent limitationssuch as multidrug-resistant pneumonia, topical and device-associated biofilm infections, and gut-localized infections where high local exposure and immunomodulatory effects may be advantageous

Lipidpolymer hybrid nanoparticles and inorganic carriers (e.g., silica nanoparticles) also improve uricase stability and targeting (Wang et al., 2025)

: 500 mg L-

Then, PBECs were washed twice in PBS and then analyzed by flow cytometry using CytoFLEX (BeckmanCoulter)