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Interplay among oxidative stress, methylglyoxal pathway and s-glutathionylation

An illustrative non-limiting substitution in a position corresponding to one or more of positions 273, 276, 306 , 326, 332, 338, 420 and / or 424 is an acidic or neutral amino acid residue, such as Asp (D), Glu (E), Ala (A), Gly (G), Ser (S), Cys (C), Asn (N), Gln (Q), Ile (I), Leu (L), Met (M), Phe (F), Pro (P), Thr (T), Trp (W), Tyr (Y) or Val (V), for example substitutions by A or E

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Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer