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Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension

This mutation results in decreased translation of G6PD and leads to 2040% residual G6PD activity (class III deficiency) in G6PDX mice compared with wild-type (WT) littermate control mice

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This aligns with the natural cycle of growth hormone stimulation and the time required for meaningful tissue remodeling