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Brain, Behavior, and Immunity 2012

This is often one of the earliest and most characteristic signs of thrombocytopaenia Easy bruising: Bruises that develop after minor impact or appear larger and last longer than usual Prolonged bleeding from cuts: Minor cuts or wounds that take longer than expected to stop bleeding Spontaneous nosebleeds: Frequent or prolonged nosebleeds without a clear trigger Heavy menstrual bleeding: Periods that are heavier or last longer than usual in women Blood in urine or stools: Pink, red, or dark-coloured urine or stools, which may indicate internal bleeding and require immediate medical attention Fatigue and weakness: Often seen alongside anaemia, which can occur with low platelet counts in certain conditions If these symptoms develop or worsen, especially in combination, it is important to seek medical evaluation promptly

Cys-Gly can then be further cleaved by various peptidases to release its constituent amino acids 43