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Increased translation as a novel pathogenic mechanism in Huntingtons disease

Le Gal K et al

Effect of Pretreatment with VPA and EMPA (1&3 mg/kg) on Immune-Expression of Apoptotic Marker (BAX) and Astrocyte Proliferation Marker (GFAP) in Hippocampal Sections in win- PTZ Induced Kindling in rats Results demonstrated that PTZ induced apoptosis in the hippocampal tissues, where the PTZ group showed diffuse brown immunostaining against BAX in the cytoplasm of CA3 neurons (Fig

The present findings demonstrate that SalA ameliorates behavioural and molecular signatures of age-dependent neurodegeneration in Drosophila , indicating that it promotes neuronal and systemic resilience with aging