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Similarly, in human lung carcinoma A549 cells, mangiferin exhibits antineoplastic properties, by inducing G2/M phase cell cycle arrest via downregulation of the cyclin-dependent kinase 1-cyclin B1 signaling pathway and inducing apoptotic cell death by inhibiting the PKC-NF-B pathway (55)

Even if some studies show notable improvements, others are unable to reproduce these advantages in demanding clinical settings

For some people with end-stage kidney disease, a kidney transplant may be the best treatment option

Oxidative stress releases pro-inflammatory molecules that interact with ROS to produce inflammation, performing major role in early onset of aging and metabolic diseases [7]