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Both parameters differentiated patients with LSM above 6.5 kPa and signs of portal hypertension from those with LSM below 6.5 kPa with an AUROC of 0.87 (TSP2) and 0.85 (IGFBP7) and outperformed PRO-C3 (0.65)

Therapeutic peptides are often based on their endogenous counterparts but may possess various modifications that improve their stability, selectivity, pharmacokinetics, safety, and effectiveness

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The Schwartz patent references the use of the measured levels of constituents of the pathway as indicators of the need to administer the constituents of the SAM pathway, and references cysteine and glutathione as an indicator of dysfunction of the SAM pathway