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77 ShinJ.-H.BlayS.McNeneyB.GrahamJ

295 In the liver and muscle cells of old mice, CR delayed the loss of constitutive heterochromatin and inhibited the expression of repetitive components, including LINE1 and satellite components, which were in the centromeric, pericentromeric, and telomeric region

In the prevalent sequential progression model, cancer cells first spread to regional LNs and then disseminate to distant organs via the lymphatic system (149)