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45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 SIRT proteins also maintain energy homeostasis in response to both nutrient deprivation and energy expenditure by inhibiting adipogenesis and promoting lipolysis

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Consistent with the clinical observations of hyperprogression in response to nivolumab plus ipilimumab, the preclinical combination of anti-PD-1 plus anti-CTLA-4 (ICT) resulted in significantly increased primary tumor mass (Fig

Our data, however, implies that in cells TPX2 preferentially binds a CEP192-dependent pool of Aurora-A, most likely carrying activation loop phosphorylation