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183,184,185,186 Panobinostat, an oral broad-spectrum HDAC inhibitor approved in January 2015 for R/R MM in combination with dexamethasone and bortezomib, showed a slight overall survival benefit in phase II and III trials

This tool, adapted from the Cochrane Collaborations RoB framework for use in preclinical animal research, allows systematic evaluation of potential sources of bias across ten domains grouped into five main categories: selection, performance, detection, attrition, and reporting bias

On day 6 of differentiation, the medium was changed to glucose/phenol red/glutamine/pyruvate-free DMEM (Thermo Fisher Scientific) supplemented with 0.5% FCS, 4.5 g l 1 glucose, 4 mM glutamine, 0.5 mM pyruvate and 5 g ml 1 insulin