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it is released in pulses

36 These frameworks suggest that the pathophysiology of AD is characterized by phosphorylated tau accumulation and propagation, 31 heightened inflammatory responses, dysregulation of oxidative stress (related to mitochondrial dysfunction), 37 alongside a gradual decline in cholinergic function

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The DAC molecule has a milder version of the same problem, not an exemption from it: at 5001,000 mcg twice weekly a 5 mg vial is consumed in 2.55 weeks, but at the 300400 mcg low end of its documented range the same vial takes 68 weeks also far outside a 12 week reconstituted window