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However, survival to CEN6 loss and thereby the frequency of radiation-induced chromosome rearrangements were markedly lower in cells depleted of oxygen relative to cells maintained in normoxia

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Oxid Med Cell Longev 9:2019 Paroni R, Terraneo L, Bonomini F, Finati E, Virgili E, Bianciardi P, Favero G, Fraschini F et al (2014) Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling